effect of leptin receptor q223r polymorphism on breast cancer risk

Authors

ghorban mohammadzadeh hyperlipidemia research center, department of clinical biochemistry, faculty of medicine, ahvaz jundishapur university of medical sciences, ahvaz, iran

mohammad-ali ghaffari cellular and molecular research center, department of clinical biochemistry, faculty of medicine, ahvaz jundishapur university of medical sciences, ahvaz, iran

ahmmad bafandeh department of clinical biochemistry, faculty of medicine, ahvaz jundishapur university of medical sciences, ahvaz, iran

sayed-mohammad hosseini department of radiation and oncology of golestan university hospital, faculty of medicine, ahvaz jundishapur university of medical sciences, ahvaz, iran

abstract

objective(s):leptin receptor (lepr) is a member of the class i cytokine receptor super-family that is known implicated in the initiation and progression of breast cancer. we have investigated the effect of q223r polymorphism on the breast cancer susceptibly in a sample of iranian subjects. materials and methods:we utilized a polymerase chain reaction (pcr) restriction fragment length polymorphism (rflp) method to investigate the association ofleprq223r polymorphism with breast cancer risk in a case control study consisting of 100 breast cancer cases and 100 controls without breast cancer. serum levels of leptin and soluble leptin receptor (sob-r) were measured by elisa method. results:the genotype (qq, qr, and rr) distributions were 25, 56, and 19 % in breast cancer cases and 54, 40, and 6% in controls, respectively. the frequency of 223 rr genotype was significantly elevated in breast cancer cases as compared to controls (χ2= 20.072, p<0.001). similar significance differences were also found in allele frequencies for q and r between two groups (χ2= 19.027, p< 0.001). additionally, there weresignificant association between q223r genotypes and breast cancer risk; homozygotes for rr genotype (or= 6.840; 95% confidence interval [ci] = 2.434-19.218), heterozygotes for qr (or=3.024; 95% ci = 1.620-5.644, p = 0.001), and qr+rr genotype (or= 3.522; 95% ci = 1.934-6.414, p < 0.001), respectively. conclusion:our results showed thattheleprq223r polymorphism is associated with increased breast cancer risk as well as tumor grade in a sample of iranian subjects.

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Journal title:
iranian journal of basic medical sciences

جلد ۱۷، شماره ۸، صفحات ۵۸۸-۵۹۴

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